The mid-18th century building that now houses the Cathedral Museum was originally a seminary. From 1858 onwards, the seminary was gradually phased out, and the building took on a number of different functions, until finally an exhibition of Marian Art held at the premises in 1949 inspired the ecclesiastical authorities to transform it into the Cathedral Museum. On January 4, 1969 the Museum was officially opened. All the paintings, silver, ecclesiastical textiles and other artifacts, which were formerly exhibited in the restricted space around the nearby Aula Capitularis inside the Mdina Cathedral, were moved out of the Cathedral to be accommodated in the new museum. This transformation established the Cathedral Museum as one of the leading Maltese cultural institutions. The year 2004 saw the start of an active refurbishment programme.
Links to the site plans of the Museum's floors are provided below: